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in “universal” influenza virus antibodies: the rise of a hidden trimeric interface in hemagglutinin globularhead

Yulu Wang, Dan Hu, Yanling Wu, Tianlei Ying

《医学前沿（英文）》 2020年第14卷第2期页码 149-159 doi: 10.1007/s11684-020-0764-y

摘要： Influenza causes seasonal outbreaks yearly and unpredictable pandemics with high morbidity and mortality rates. Despite significant efforts to address influenza, it remains a major threat to human public health. This issue is partially due to the lack of antiviral drugs with potent antiviral activity and broad reactivity against all influenza virus strains and the rapid emergence of drug-resistant variants. Moreover, designing a universal influenza vaccine that is sufficiently immunogenic to induce universal antibodies is difficult. Some novel epitopes hidden in the hemagglutinin (HA) trimeric interface have been discovered recently, and a number of antibodies targeting these epitopes have been found to be capable of neutralizing a broad range of influenza isolates. These findings may have important implications for the development of universal influenza vaccines and antiviral drugs. In this review, we focused on the antibodies targeting these newly discovered epitopes in the HA domain of the influenza virus to promote the development of universal anti-influenza antibodies or vaccines and extend the discovery to other viruses with similar conformational changes in envelope proteins.

关键词： influenza virus neutralizing antibody hemagglutinin globular head region trimeric interface

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Expression pattern and regulation of head-to-head genes

Xinxing CUI,Chunhong YANG,Li KANG,Guiyu ZHU,Qingqing WEI,Yunliang JIANG

《农业科学与工程前沿（英文）》 2014年第1卷第2期页码 130-136 doi: 10.15302/J-FASE-2014013

摘要： Vacuolar protein sorting 36 (VPS36), a protein primarily known for its role in the Endosomal Sorting Complex Required for Transport pathway, has recently been shown to be linked to chicken reproduction. Previous research showed that is significantly downregulated in sexually mature chicken ovaries compared to immature ones. In this study, using real-time quantitative RT-PCR, we investigated the expression pattern of and its head-to-head gene mRNA in chicken follicles. Small white follicles were found to have significantly higher expression of and mRNA than any other sized follicles ( <0.05). The expression of and mRNA were detected in both granulosa and theca layers of pre-ovulatory follicles, the expression of in theca layers was slightly higher than in granulosa cells. Treatment of small yellow follicles with follicle-stimulating hormone and estradiol resulted in a marked decrease of both and mRNA ( <0.05); however, progesterone, transforming growth factor-β 1 and luteinizing hormone induced no significant changes in and mRNA expression in these follicles. These results indicate that the head-to-head genes of and exhibit similar expression in chicken follicles and are involved in chicken follicle development.

关键词： chicken Vps36 Ckap2 mRNA follicle

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Basic consideration of research strategies for head and neck cancer

null

《医学前沿（英文）》 2012年第6卷第4期页码 339-353 doi: 10.1007/s11684-012-0213-7

摘要：

Head and neck cancer (HNC) consists of a group of malignancies affecting closely related anatomical regions of the upper aerodigestive tract (UADT), including the oral cavity, salivary glands, upper and lower jaw bones and facial skin; the nasal cavity, paranasal sinuses, pharynx, larynx and thyroid gland (although the latter is often excluded and considered as part of endocrine neoplasms). Of these, 90% of HNCs are histologically squamous cell carcinomas originating from the mucosal lining. These malignancies are strongly associated with certain environmental and life-style risk factors, principally tobacco in both smoked and smokeless forms, excessive alcohol consumption, diets poor in antioxidants and essential micronutrients, UV light, chemicals used in certain workplaces, and viruses, principally certain strains of human papillomavirus (HPV) and Epstein-Barr virus (EBV). These cancers are frequently aggressive in their biological behaviour with local invasion and metastasis to lymph nodes in the neck. Since most patients are already at late stages of disease at the time of diagnosis, the desirable practice of early diagnosis (first sign of the malignant lesion at an initial stage ) and early treatment, a critical priority to save lives and retain quality of life, is difficult to implement. Thus, primary prevention has been set as a key goal. This article aims to reinforce the basic knowledge of aetiology, key risk factors related to the development of head and neck cancer, basic features of clinical appearance of this group of cancers, and strategies for prevention and early detection. We also suggest basic research strategies on the basis of current knowledge, which should ultimately lead to the improvement of clinical management.

关键词： clinical management head and neck cancer prevention and early detection research strategies risk factors

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Influence of surface cracking, anchor head profile, and anchor head size on cast-in headed anchors in

《结构与土木工程前沿（英文）》页码 1163-1187 doi: 10.1007/s11709-023-0987-5

摘要： In this study, the concrete cone capacity, concrete cone angle, and load–displacement response of cast-in headed anchors in geopolymer concrete are explored using numerical analyses. The concrete damaged plasticity (CDP) model in ABAQUS is used to simulate the behavior of concrete substrates. The tensile behavior of anchors in geopolymer concrete is compared with that in normal concrete as well as that predicted by the linear fracture mechanics (LFM) and concrete capacity design (CCD) models. The results show that the capacity of the anchors in geopolymer concrete is 30%–40% lower than that in normal concrete. The results also indicate that the CCD model overestimates the capacity of the anchors in geopolymer concrete, whereas the LFM model provides a much more conservative prediction. The extent of the difference between the predictions by the numerical analysis and those of the above prediction models depends on the effective embedment depth of the anchor and the anchor head size. The influence of concrete surface cracking on the capacity of the anchor is shown to depend on the location of the crack and the effective embedment depth. The influence of the anchor head profile on the tensile capacity of the anchors is found to be insignificant.

关键词： cast-in anchor concrete cone capacity geopolymer concrete head size surface crack anchor profile

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factors for ventilator-associated pneumonia among patients undergoing major oncological surgery for head

null

《医学前沿（英文）》 2017年第11卷第2期页码 239-246 doi: 10.1007/s11684-017-0509-8

摘要：

Patients undergoing major oncological surgery for head and neck cancer (SHNC) have a particularly high risk of nosocomial infections. We aimed to identify risk factors for ventilator-associated pneumonia (VAP) in patients undergoing SHNC. The study included 465 patients who underwent SHNC between June 2011 and June 2014. The rate of VAP, risk factors for VAP, and biological aspects of VAP were retrospectively evaluated. The incidence of VAP was 19.6% (n=95) in patients who required more than 48 h of mechanical ventilation. Staphylococcus (37.7%), Enterobacteriaceae (32.1%), Pseudomonas(20.8%), and Haemophilus (16.9%) were the major bacterial species that caused VAP. The independent risk factors for VAP were advanced age, current smoking status, chronic obstructive pulmonary disease, and a higher simplified acute physiology score system II upon admission. Tracheostomy was an independent protective factor for VAP. The median length of stay in the ICU for patients who did or did not develop VAP was 8.0 and 6.5 days, respectively (P=0.006). Mortality among patients who did or did not develop VAP was 16.8% and 8.4%, respectively (P<0.001). The potential economic impact of VAP was high because of the significantly extended duration of ventilation. A predictive regression model was developed with a sensitivity of 95.3% and a specificity of 69.4%. VAP is common in patients who are undergoing SHNC and who require more than 48 h of mechanical ventilation. Therefore, innovative preventive measures should be developed and applied in this high-risk population.

关键词： ventilator-associated pneumonia (VAP) pneumonia risk factors surgery for head and neck cancer (SHNC)

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Model test study for ice force on the bank-head of the lead-navigating bank

SONG An, SUN Jinliang, LU Hai, WANG Yi′an

《结构与土木工程前沿（英文）》 2007年第1卷第2期页码 222-228 doi: 10.1007/s11709-007-0027-x

摘要： To determine the bank-head s ice force of the lead-navigating bank at key position that faces the ice directly of certain water conservancy, ice model test in reduced scale is designed and carried out based on the local situation on the spot and data observed. Preliminary conclusions are got through the analysis of the experimental data such as effect of the ice velocity on the ice force , ratio of components of forces when ice sheet acting on the vertical bank-head, ice force ratio of vertical to 45? incline as well as ratio of level ice force to the vertical ice force when acting on 45? incline. Finally, suggestions on determination of the ice force using formula are given after comparison between the result calculated by the present formula of ice force and the experimental results.

关键词： comparison lead-navigating bank vertical bank-head certain Preliminary

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Biologically inspired model of path integration based on head direction cells and grid cells

Yang ZHOU,De-wei WU

《信息与电子工程前沿（英文）》 2016年第17卷第5期页码 435-448 doi: 10.1631/FITEE.1500364

摘要： Some neurons in the brain of freely moving rodents show special firing pattern. The firing of head direction cells (HDCs) and grid cells (GCs) is related to the moving direction and distance, respectively. Thus, it is considered that these cells play an important role in the rodents’ path integration. To provide a bionic approach for the vehicle to achieve path integration, we present a biologically inspired model of path integration based on the firing characteristics of HDCs and GCs. The detailed implementation process of this model is discussed. Besides, the proposed model is realized by simulation, and the path integration performance is analyzed under different conditions. Simulations validate that the proposed model is effective and stable.

关键词： Head direction cells (HDCs) Grid cells (GCs) Path integration Bionic navigation

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Ultramicrostructure and clinical implications of satellite foci in front of the head of pterygium

LIU Haixia, XIANG Nan, ZHOU Xiongwu, HU Weikun, LI Guigang, ZHANG Hong

《医学前沿（英文）》 2007年第1卷第2期页码 211-214 doi: 10.1007/s11684-007-0040-4

摘要： In our previous studies, grey satellite foci were found in the front of heads of pterygia. This research was designed to investigate the ultramicrostructure and clinical implications of these satellite foci. The satellite foci were observed and counted under slit lamp biomicroscope. The patients with eye pterygia were divided into groups in terms of occupation, sex, age, length of history, grade of congestion, and size of the heads. The SPSS 13.0 software was used for statistical analysis. The cap areas and satellite foci were ultramicrostructurally examined. Among the total 62 eyes with pterygium, satellite foci were found in 34. The overall incidence of satellite foci was 54.8%. There were no significant differences in incidence among the subjects of different sex, age, and length of history. There were significant differences in incidence among the patients of different occupation, grades of congestion, and size of heads. Higher grades of congestion, outdoor occupations and larger pterygium heads were associated with higher incidence of satellite foci. High grades of congestion and bigger heads were also correlated with the number of satellite foci. Length of history bore no correlation with number of satellite foci. Histologically, the components of the cap areas and the foci were identical, with both consisting of mass of active fibroblasts. The activated fibroblasts existed in the natural tissue planes between Bowman s layer and basal cell layer. The fibroblasts in the satellite foci and the cap areas of a pterygium show some features of tumor cells and may play a vital role in the development and progression of a pterygium. The presence and amount of satellite foci around a pterygium can be used as an indicator for the speed of its growth.

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前往火星的三个太空任务

Mitch Leslie

《工程（英文）》 2020年第6卷第12期页码 1336-1338 doi: 10.1016/j.eng.2020.10.007

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The comparative study of dwelling houses in the southwest multi-ethnic region, taking Fugong county for

Fang WANG, Jiaping LIU

《结构与土木工程前沿（英文）》 2010年第4卷第4期页码 474-482 doi: 10.1007/s11709-010-0089-z

摘要： A number of ethnic minorities are being distributed in southwest China. Yunnan Province is an area inhabited by multi-ethnic groups. For a long time, the ethnic groups have been interacted by others in the cultural aspect, while retaining their own ethnic traditions. The performances of ethnic groups’ dwelling houses are similar as determined by natural and cultural elements of the same area. This paper mainly analyzes decisive factors behind similar appearances by the way of field research on two minorities, Nu ethnic group and Li-su ethnic group, in the Fugong county, Nujiang Li-su autonomous prefecture. Moreover, the paper tries to summarize the commonality and individuality of the minorities in order to provide useful theoretical reference for the minorities building of new socialist countryside in the future.

关键词： Nu ethnic group Li-su ethnic group mixed region living culture living mode living acts

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基因组测序成本将再次降低

Robert Pollie

《工程（英文）》 2023年第23卷第4期页码 3-6 doi: 10.1016/j.eng.2023.02.002

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高速线材吐丝机吐丝管空间曲线研究和改进

刘宏民,姚双吉,杨利坡,庞志峰,李双来,刘武斌,闫胜友,褚建东

《中国工程科学》 2006年第8卷第11期页码 80-85

摘要：

针对唐钢高线吐丝机存在的吐丝质量问题，采用三次样条拟合现场实测数据得到吐丝管曲线方程；根据吐丝管中线材的速度和受力模型，分析线材在吐丝管中的运动状态，研究吐丝管空间曲线对吐丝质量的影响，得到吐丝管空间曲率波动过大和出口速度变化过快是导致吐丝质量不好的主要原因；通过改善吐丝管空间曲线和规范煨管工艺制度，显著改善了甩尾、吐圈摆动等吐丝质量，吐丝管寿命提高了1倍。

关键词：高速吐丝机吐丝管空间曲线

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微水头资源开发与发电装置研究现状及趋势

张玉全,郑源,孙科,杨春霞,罗红英

《中国工程科学》 2018年第20卷第3期页码 90-95 doi: 10.15302/J-SSCAE-2018.03.013

摘要：

我国水能资源丰富，开发水力发电技术是增加可再生能源供应、优化能源结构、缓解环境问题的优先选择。本文着眼于我国丰富的微水头资源，梳理河流、运河、水库、电厂尾水、管道供水、城市废水、海洋新能源等微水头资源需求和应用特点，总结适合开阔流域和封闭流域特点的两型微水头水力发电水轮机，对形成动势能结合型微水头水轮机设计方法和研究其流动特征和机理提供基础。介绍了微水头资源评估和水力发电水轮机研究的趋势，并对今后研究方向提出了建议。

关键词：微水头资源水力发电水轮机开阔流域封闭流域

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Protective roles of heat stress on the neurons in hippocampal CA1 region of mice

WANG Chunxu, WANG Hanxing

《医学前沿（英文）》 2007年第1卷第4期页码 418-422 doi: 10.1007/s11684-007-0082-7

摘要： The effects of heat stress on the neurons in hippocampal CA1 region of brain ischemia/reperfusion were explored. The mice were pretreated with heat stress followed by ischemia/reperfusion by clipping bilateral cervical commo n arteries for 7 min. Mice were divided randomly into four groups as follows: (1) normal control group; (2) heat stress pretreated subsequent to ischemia/reperfusion group (HS/IR); (3) ischemia/reperfusion group (IR); and (4) heat stress group (HS). Animals in the last three groups were subdivided into three subgroups: 1 d, 4 d, 14 d respectively. The Morris water maze was used to test the ability of learning and memorizing, Nissl staining was used to count the average number of survived neurons in hippocampal CA1 region, and immunohistochemistry combined with image analysis system to detect the changes of Microtubule associated protein 2 (MAP-2) expression. The results showed that mice in IR group exhibited increased escape latency when compared with that of normal, HS and HS/IR groups (<0.01), and the mice in IR group adopted an inefficient search strategy, major in circling and restricted searching manners. Nissl staining results showed a significant reduction in the number of pyramidal neurons in hippocampal CA1 regions in HS/IR and IR groups, with a decrease in IR group (<0.01). Compared with normal group, the expression of MAP-2 in hippocampal CA1 region obviously decreased in IR group (<0.05). The present results indicate that heat stress pretreatment can improve the spatial learning and memorizing function through protection to hippocampal neurons.

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Bioaerosol emissions variations in large-scale landfill region and their health risk impacts

《环境科学与工程前沿（英文）》 2022年第16卷第12期 doi: 10.1007/s11783-022-1593-9

摘要：

● The airborne bacteria in landfills were 4–50 times higher than fungi.

关键词： Microbial aerosols Landfill sites Health risk assessment CALPUFF